3,4-Difluorobenzyl alcohol → 2-(3,4-Difluorobenzyloxy)-4-(amino)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine
반응식
CS([C:5]1[N:10]=[C:9]([NH2:11])[C:8]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:7]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[Cl:26])[N:6]=1)(=O)=O.[F:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][C:35]=1[F:36])[CH2:31][OH:32]>>[F:27][C:28]1[CH:29]=[C:30]([CH:33]=[CH:34][C:35]=1[F:36])[CH2:31][O:32][C:5]1[N:10]=[C:9]([NH2:11])[C:8]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[C:7]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][C:20]=2[Cl:26])[N:6]=1참가 물질
3
실험 절차
The title compound obtained by treating 2-(methylsulfonyl)-4-(amino)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine (Example 32, Step A,) with 3,4-difluorobenzyl alcohol by the same general procedure described in Reference Examples 6 and 7. Workup and flash column chromatography on silica gel (eluted with 80/20 hexanes/ethyl acetate) afforded 2-(3,4-difluorobenzyloxy)-4-(amino)-5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)pyrimidine. HPLC/MS: m/e=494 (M++1); Rt=3.91 min. 1H-NMR 500 MHz (CDCl3): δ 5.10 (bs, 2H), 5.38 (s, 2H), 7.0-7.10 (m, 2H), 7.11-7.23 (m, 6H), 7.15-7.19 (m, 2H).
출처 및 근거
- ORD 기록
- ord-5b4bae449eaf4839a3703b1f29d322f8
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07405221B2
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