Oxalyl chloride → 7-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

HRID 75084노트

반응식

HRID 75084 반응식
[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:19])[CH:14]3[CH:15]([C:16](O)=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3].C(Cl)(=O)C([Cl:23])=O>C1(C)C=CC=CC=1>[C:1]([O:6][CH:7]1[CH:11]2[O:12][C:13](=[O:19])[CH:14]3[CH:15]([C:16]([Cl:23])=[O:17])[CH:8]1[CH2:9][CH:10]23)(=[O:5])[C:2]([CH3:4])=[CH2:3]

참가 물질

4

반응물 2

HCID 65578Oxalyl chlorideHCID 206800246-Methacryloyloxy-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-7-carboxylic Acid

생성물 1

HCID 866409437-Chlorocarbonyl-2-oxohexahydro-3,5-methano-2H-cyclopenta[b]furane-6-yl Methacrylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Suspended into 135 mL of toluene was 18.0 g of the carboxylic acid (26) obtained in Synthesis Example 1-1-2, and then into the resulting suspension was gradually added 10.3 g of oxalyl chloride at 80° C. After this mixture was stirred for 4 hours, toluene was removed by distillation under reduced pressure to obtain the intended product. The obtained acid chloride was used in the next reaction without further purification.

후처리

  1. customobtained in Synthesis Example 1-1-2
  2. customat 80° C
  3. customtoluene was removed by distillation under reduced pressure
  4. customto obtain the intended product

출처 및 근거

ORD 기록
ord-fe22ae6ffcae43baacdaa4e45626e590
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835097B2

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