Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Tert-butyl {3-[3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazol-1-yl]-1,1-dimethyl-propyl}-carbamate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-(4-Fluoro-phenyl)-5-methyl-[1,2,4]triazole | HCID 43166756 | — |
| 반응물 | tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate | HCID 57429079 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 용매 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 생성물 | Tert-butyl {3-[3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazol-1-yl]-1,1-dimethyl-propyl}-carbamate | HCID 66886384 | — |
반응 단계
5.88 g (33 mmol) 3-(4-fluoro-phenyl)-5-methyl-[1,2,4]triazole are dissolved in 40 mL DMPU and reacted with 11.04 g (50 mmol) tert-butyl(3-chloro-1,1-dimethyl-propyl)-carbamate, 1.59 g (40 mmol, 60%) sodium hydride and 2.21 g (6 mmol) tetrabutylammonium iodide as described for intermediate product 1c).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07405232B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-43acf2c4c99b4d0cb767577bf511beac |
| 출처 메모 | uspto-grants-2008_07 |