Trichloroacetic Acid → (S)-N-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-trichloroacetamide

HRID 750930

반응식

HRID 750930 반응식
[C:1]([C:3](=[C:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:21][C@H:20]([CH2:22][NH2:23])[O:19][C:18]3=[O:24])=[CH:13][C:12]=2[F:25])[CH2:7][CH2:6]1)[CH3:4])#[N:2].[Cl:26][C:27]([Cl:32])([Cl:31])[C:28](O)=[O:29]>>[C:1]([C:3](=[C:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:21][C@H:20]([CH2:22][NH:23][C:28](=[O:29])[C:27]([Cl:32])([Cl:31])[Cl:26])[O:19][C:18]3=[O:24])=[CH:13][C:12]=2[F:25])[CH2:7][CH2:6]1)[CH3:4])#[N:2]

참가 물질

3

반응물 2

HCID 6421Trichloroacetic AcidHCID 69315435(S)-N-{3-[4-(4-(1-cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine

생성물 1

HCID 24887808(S)-N-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-trichloroacetamide수율 45%

실험 절차

The title compound was prepared by following the procedure of Example 29 and by using (S)-N-{3-[4-(4-(1-cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-amine and trichloroacetic acid in 45% yield.

출처 및 근거

ORD 기록
ord-44bab824c956480ba0f36cc6d4ab889f
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405228B2

연결된 노트

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