Diethyl (1-cyanoethyl)phosphonate → (R)-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol

HRID 750931노트

반응식

HRID 750931 반응식
O=[C:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][OH:20])[O:16][C:15]3=[O:21])=[CH:10][C:9]=2[F:22])[CH2:4][CH2:3]1.C(OP([CH:31]([C:33]#[N:34])[CH3:32])(=O)OCC)C>>[C:33]([C:31](=[C:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][C@H:17]([CH2:19][OH:20])[O:16][C:15]3=[O:21])=[CH:10][C:9]=2[F:22])[CH2:4][CH2:3]1)[CH3:32])#[N:34]

참가 물질

3

반응물 2

HCID 282103Diethyl (1-cyanoethyl)phosphonateHCID 60133490(R)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol

생성물 1

HCID 69315198(R)-{3-[4-(4-(1-Cyanoethylidene)-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol수율 63%

실험 절차

The title compound was prepared by following the procedure of Example 1 and by using (R)-{3-[4-(4-oxo-piperidin-1-yl)-3-fluorophenyl]-2-oxo-oxazolidin-5-ylmethyl}-alcohol and diethyl(1-cyanoethyl)-phosphonate in 63% yield.

출처 및 근거

ORD 기록
ord-0bf5f29d86d548618b0491e97e281474
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405228B2

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