Acetyl chloride → HCID 68954629, 화합물

HRID 750992노트

반응식

HRID 750992 반응식
[OH:1][C:2]1[CH:3]=[C:4]([N:10]([CH2:20][C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[C:27](Cl)(=O)C>CO>[OH:1][C:2]1[CH:3]=[C:4]([N:10]([CH2:20][C:21]2[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=2)[C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([O:16][CH3:27])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 10360501Benzoic acid, 3-[(3-hydroxy-4-methoxyphenyl)(3-pyridinylmethyl)amino]-

생성물 1

HCID 68954629HCID 68954629, 화합물수율 84%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-(3-Hydroxy-4-methoxyphenyl)-N-(3-pyridylmethyl)-3-aminobenzoic acid (7.0 g, 20.0 mmol) was dissolved in 210 mL of MeOH and 2.8 g (36.0 mmol) of acetyl chloride was added. The material was warmed to reflux with stirring overnight. The solution was concentrated in vacuo and then diluted with 200 mL of DCM and washed with saturated NaHCO3, brine, dried (Na2SO4), and concentrated to give 6.85 g (84% yield) of the desired target.

후처리

  1. temperatureThe material was warmed
  2. temperatureto reflux
  3. concentrationThe solution was concentrated in vacuo
  4. additiondiluted with 200 mL of DCM
  5. washwashed with saturated NaHCO3, brine
  6. dry with materialdried (Na2SO4)
  7. concentrationconcentrated
  8. customto give 6.85 g (84% yield) of the desired target

출처 및 근거

ORD 기록
ord-7d7a9209c99543d7addca56ae8930622
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405230B2

반응 노트

불러오는 중…