1-Methyl-4-nitro-1H-benzimidazole → 4-Amino-1-methylbenzimidazole
반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N+:11]([O-])=O)[C:5]=2[N:4]=[CH:3]1.[H][H]>CCO.[Pd]>[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([NH2:11])[C:5]=2[N:4]=[CH:3]1참가 물질
5
실험 절차
A suspension of 1-methyl-4-nitro-1H-benzimidazole [2.1 g, 12 mmol, prepared as described in Viktor Milata et. al., Org. Prep. Proced. Int. 25 (6), 703-704 (1993)] and 5% Pd/C (0.21 g) in EtOH (40 mL) was vigorously stirred under an atmoshphere of hydrogen at rt overnight. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford the tiltle compound (1.65 g).
후처리
- filtrationThe reaction mixture was filtered
- concentrationthe filtrate concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-af6de576f52b43a29526c64c6d613f25
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07405234B2
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