Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 5-(tert-Butyldimethylsilyloxy)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | 5-Hydroxyindole | HCID 16054 | — |
| 반응물 | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-(tert-Butyldimethylsilyloxy)-1H-indole | HCID 22250817 | 100% |
반응 단계
A solution of 5-hydroxy-indole (5 g, 38 mmol), tert-butyldimethylsilyl chloride (6.13 g, 39.4 mmol) and imidazole (5.37 g, 68.1 mmol) in DMF (50 ml) was stirred for 20 h at RT. Diethyl ether was added and the mixture was washed with 1N HCl and water. The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give 9.4 g (38 mmol, quant.) 5-(tert-butyl-dimethyl-silanyloxy)-1H-indole.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07405236B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-3f63406704fd44c7a2243ee88acf4a89 |
| 출처 메모 | uspto-grants-2008_07 |