Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N,N',N'-Tetramethylazodicarboxamide → {5-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| 반응물 | Tributylphosphine | HCID 13831 | — |
| 반응물 | (5-Hydroxy-indol-1-yl)-acetic acid ethyl ester | HCID 57675474 | — |
| 반응물 | 4-Pentyn-1-ol, 5-[4-(trifluoromethoxy)phenyl]- | HCID 68822690 | — |
| 생성물 | {5-[5-(4-Trifluoromethoxy-phenyl)-pent-4-ynyloxy]-indol-1-yl}-acetic acid ethyl ester | HCID 68822255 | — |
반응 단계
In analogy to the procedure described for example 1 d], (5-hydroxy-indol-1-yl)-acetic acid ethyl ester was reacted with 5-(4-trifluoromethoxy-phenyl)-pent-4-yn-1-ol in the presence of N,N,N′,N′-tetramethyl azodicarboxamide and tributylphosphine to give the title compound as yellow crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07405236B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-85837d0d6230447ab8156956a11dcf0e |
| 출처 메모 | uspto-grants-2008_07 |