반응식
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([OH:16])[CH:14]=2)[CH:9]=[CH:8]1)[CH3:6])[CH3:2].[F:18][C:19]([F:38])([F:37])[O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]#[C:28][CH2:29][CH2:30][CH2:31]OS(C)(=O)=O)=[CH:23][CH:22]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[I-].[K+]>>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16][CH2:31][CH2:30][CH2:29][C:28]#[C:27][C:24]3[CH:25]=[CH:26][C:21]([O:20][C:19]([F:18])([F:37])[F:38])=[CH:22][CH:23]=3)[CH:14]=2)[CH:9]=[CH:8]1)[CH3:6])[CH3:2]참가 물질
5
반응물 4
생성물 1
실험 절차
In analogy to the procedure described in example 11 c], [rac]-2-(6-hydroxy-indol-1-yl)-propionic acid ethyl ester (GB 2253848 A1) was reacted with methanesulfonic acid 5-(4-trifluoromethoxy-phenyl)-pent-4-ynyl ester (example 9 a]) in the presence of cesium carbonate and potassium iodide to give the title compound as colorless liquid.
출처 및 근거
- ORD 기록
- ord-244fb64dfeee4a8aa06781a10a19884e
- 출처 데이터셋
- uspto-grants-2008_07
- 특허 번호
- US07405236B2
연결된 노트
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