Piperidine → 2-(Piperidin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde

HRID 751337

반응식

HRID 751337 반응식
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1

참가 물질

3

반응물 2

HCID 8082PiperidineHCID 3147932-chloro-1-phenyl-1H-indole-3-carbaldehyde

생성물 1

HCID 597547562-(Piperidin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde수율 50%

실험 절차

2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with piperidine as described in Example 2 to give, after flash chromatography, the title compound (50% yield). NMR (CDCl3) 10.23 (1H, s), 8.29 (1H, d), 7.59 (2H, m), 7.50 (1H, m), 7.40 (2H, d), 7.22 (1H, m), 7.11 (1H, t), 6.98 (1H, d), 3.25 (4H, m), 1.53 (2H, m), 1.42 (4H, m).

후처리

  1. customto give

출처 및 근거

ORD 기록
ord-cc7061b6b7914ad0af4ebbe8da9612e4
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405300B2

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