Piperazine → 2-(piperazin-1-yl)-1-(pyridin-3-yl)-1H-indole-3-carboxaldehyde

반응식

Cl[CH:2]1[CH:10]([CH:11]=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1[C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]([C:13]3[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1

참가 물질

반응물 2

HCID 4837Piperazine

HCID 86035953HCID 86035953, 화합물

생성물 1

HCID 112897502-(piperazin-1-yl)-1-(pyridin-3-yl)-1H-indole-3-carboxaldehyde수율 23%

실험 절차

2-chloro-1-(pyridin-3-yl)-1,3-dihydroindole-3-carboxaldehyde is reacted with piperazine as described in Example 2 to give, after flash chromatography, the title compound (23% yield).

후처리

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출처 및 근거

ORD 기록: ord-e7bc8de74402479691c4d1c7197e0ee7
출처 데이터셋: uspto-grants-2008_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07405300B2

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