Water → 3-(Cyanomethyl)pyridin-1-ium-1-olate

HRID 751350노트

반응식

HRID 751350 반응식
C(OO)(=[O:3])C.[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][C:13]#[N:14])[CH:7]=1.O>C(O)(=O)C>[CH:10]1[CH:11]=[N+:6]([O-:3])[CH:7]=[C:8]([CH2:12][C:13]#[N:14])[CH:9]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 6585Peracetic AcidHCID 809233-Pyridineacetonitrile

생성물 1

HCID 2431673-(Cyanomethyl)pyridin-1-ium-1-olate

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
95 °C

실험 절차

The title compound is prepared in accordance with the procedures as outlined in S. Okuda et al., J. Am. Chem. Soc., 81, 740, (1959). Peracetic acid (38%, 40 mL, 0.2 mol) is added to a stirred solution of 3-pyridylacetonitrile (15.0 g, 127 mmol) in acetic acid (75 mL) and the reaction is heated at 95° C. for 24 hr, then stirred at room temperature for 24 hr. Water is added and the solvents are removed. More water (100 mL) is added and again removed. This process is repeated with toluene and with ether to give (1-oxypyridin-3-yl)acetonitrile as a cream solid.

후처리

  1. customThe title compound is prepared in accordance with the procedures
  2. customthe solvents are removed
  3. additionMore water (100 mL) is added
  4. customagain removed

출처 및 근거

ORD 기록
ord-735dcf326d3e463d8f672432138e8564
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405300B2

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