Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,6-Dimethylpiperazine → 2-(3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,6-Dimethylpiperazine | HCID 66056 | — |
| 반응물 | 2-chloro-1-phenyl-1H-indole-3-carbaldehyde | HCID 314793 | — |
| 생성물 | 2-(3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde | HCID 11199518 | — |
반응 단계
2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with 2,6-dimethylpiperazine as described in Step 2 of Example 29 to afford 2-(3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde as a solid. The solid is dissolved in methanol, treated with 1M ethereal hydrochloric acid and concentrated. The residue triturated with ether to give 2-(3,5-dimethylpiperazin-1-yl)-1-phenyl-1H-indole-3-carboxaldehyde hydrochloride (74% yield) as a purple solid. ESI/MS 334 (M+H); RT=2.52 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07405300B2 |
| 출처 데이터셋 | uspto-grants-2008_07 |
| ORD ID | ord-5a921347532b4b4f89c56150f24850f5 |
| 출처 메모 | uspto-grants-2008_07 |