Methanol → Tricyclo(3.3.1.13,7)dec-1-ylmethylamine
반응식
[C:1]12([C:11]([NH2:13])=O)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.S(C)C.CO>C1COCC1>[C:1]12([CH2:11][NH2:13])[CH2:8][CH:7]3[CH2:6][CH:5]([CH2:4][CH:3]([CH2:9]3)[CH2:2]1)[CH2:10]2참가 물질
5
실험 절차
To a solution of admantane-1-carboxamide (2 g, 11.17 mmol) in THF (50 mL) was added BH3.Me2S (10.2 M, 3.4 mL, 34.7 mmol) under nitrogen. The mixture was heated at reflux overnight. The solution was cooled to rt. Methanol (20 mL) was added to the solution. The mixture was concentrated under vacuum to give crude product, which was purified by chromatography on silica gel to afford (1-adamantyl)methylamine (1.09 g, 59%). 1H NMR (CDCl3, 400 MHz): δ=1.44-1.96 (m, 15H), 2.30 (s, 2H).
후처리
- temperatureThe mixture was heated
- temperatureat reflux overnight
- concentrationThe mixture was concentrated under vacuum
- customto give crude product, which
- customwas purified by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-6ea67caa19ef43d084cf1bbdb95ce0e3
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08835426B2
반응 노트
불러오는 중…