Pyridine → Darinaparsin

HRID 751477

반응식

HRID 751477 반응식
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[CH3:21][As:22]([CH3:24])Cl.N1C=CC=CC=1>COCCOC>[CH3:21][As:22]([CH3:24])[S:13][CH2:12][C@@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[NH:10][C:8](=[O:9])[CH2:7][CH2:6][C@@H:2]([C:3]([OH:5])=[O:4])[NH2:1]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 11200ChlorodimethylarsineHCID 124886Glutathione

생성물 1

HCID 11683005Darinaparsin

시약·촉매·용매 1

HCID 80711,2-Dimethoxyethane용매

실험 절차

In a 500 mL flask, 7 g of glutathione was used as received from the Aldrich Chemical Co., purity 98% and dissolved in 250 mL of 1,2-dimethoxyethane. To this solution was added 3.3 g of dimethylchloroarsine. This was followed by the addition of 3.5 g of pyridine (redistilled after drying over NaOH pellets). The solution was refluxed for one hour after which time it was stirred at room temperature for three hours.

후처리

  1. temperatureThe solution was refluxed for one hour after which time it

출처 및 근거

ORD 기록
ord-1d2d7a40ffad4f6f89dc233d9c543997
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405314B2

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