Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Adamantanecarboxylic acid → N-(3-hydroxybutyl)adamantane-1-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Adamantanecarboxylic acid | HCID 13235 | — |
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-Butanol, 4-amino- | HCID 170254 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(3-hydroxybutyl)adamantane-1-carboxamide | HCID 59437164 | 30.2% |
반응 단계
Adamantane-1-carboxylic acid (404 mg, 2.24 mmol), 4-amino-butan-2-ol (200 mg, 2.24 mmol), EDCI (885 mg, 4.48 mmol) and HOBt (605 mg, 4.48 mmol) were dissolved in anhydrous CH2Cl2. DIEA (1.444 g, 11.2 mmol) was added to the above mixture at 0° C. under nitrogen. The mixture was stirred overnight and concentrated to give a residue, which was purified by preparative TLC to provide N-(3-hydroxybutyl)adamantane-1-carboxamide (170 mg, 30%). 1H NMR (MeOD, 400 MHz): δ=1.20 (d, 3H), 1.66˜2.04 (m, 17H), 2.87 (m, 2H), 3.79(m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835426B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-0bbed32b62c949fca5a7680e4c4e397f |
| 출처 메모 | uspto-grants-2014_09 |