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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Dichloromethane → (S)-2-(3,5-Difluorophenyl)-1-((3S,9S,13S,15R,19S,22S)-15, 19-Dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetraaza-tetracyclo[20.4.0.03,7.013,17]hexacos-9-ylcarbamoyl)-ethylammonium 2,2,2-trifluoroacetate

HRID 751763
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HRID 751763 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C@H:10]([NH:47]C(=O)OC(C)(C)C)[C:11](=[O:46])[NH:12][C@H:13]2[CH2:38][O:37][C:36](=[O:39])[C@H:35]3[N:31]([CH2:32][C@H:33]([CH3:40])[CH2:34]3)[C:30](=[O:41])[C@H:29]([CH3:42])[NH:28][C:27](=[O:43])[C@H:26]3[N:21]([CH2:22][CH2:23][CH2:24][CH2:25]3)[C:20](=[O:44])[C@H:19]3[N:15]([CH2:16][CH2:17][CH2:18]3)[C:14]2=[O:45])[CH:5]=[C:6]([F:8])[CH:7]=1.ClCCl.[F:58][C:59]([F:64])([F:63])[C:60]([OH:62])=[O:61]>O>[F:58][C:59]([F:64])([F:63])[C:60]([O-:62])=[O:61].[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C@H:10]([NH3+:47])[C:11](=[O:46])[NH:12][C@H:13]2[CH2:38][O:37][C:36](=[O:39])[C@H:35]3[N:31]([CH2:32][C@H:33]([CH3:40])[CH2:34]3)[C:30](=[O:41])[C@H:29]([CH3:42])[NH:28][C:27](=[O:43])[C@H:26]3[N:21]([CH2:22][CH2:23][CH2:24][CH2:25]3)[C:20](=[O:44])[C@H:19]3[N:15]([CH2:16][CH2:17][CH2:18]3)[C:14]2=[O:45])[CH:3]=[C:2]([F:1])[CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59753410tert-Butyl [(S)-2-(3,5-difluorophenyl)-1-((3S,9S,13S,15R,19S,22S)-15,19-dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetraaza-tetracyclo-[20.4.0.03,7.013,17]hexacos-9-ylcarbamoyl)-ethyl]-carbamate

생성물 1

HCID 86598033
(S)-2-(3,5-Difluorophenyl)-1-((3S,9S,13S,15R,19S,22S)-15, 19-Dimethyl-2,8,12,18,21-pentaoxo-11-oxa-1,7,17,20-tetraaza-tetracyclo[20.4.0.03,7.013,17]hexacos-9-ylcarbamoyl)-ethylammonium 2,2,2-trifluoroacetate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

485 mg (0.64 mmol) of the compound from example 28A are introduced into dichloromethane (7 ml) at 0° C. 7 ml of a solution of 9 parts by volume of trifluoroacetic acid and 1 part of water are added and the reaction mixture is stirred for 45 min. The solvent is removed in vacuo and the residue is in each case taken up using dichloromethane and subsequently using toluene and concentrated to dryness. 588 mg of crude product are obtained, which is employed in the subsequent step without further purification.

후처리

  1. customThe solvent is removed in vacuo
  2. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-da3dda5360b84ac3ad9912c6c9dee906
출처 데이터셋
uspto-grants-2008_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07405201B2

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