Thionyl Chloride → 3-Cyclohexylprop-2-enoyl chloride

HRID 751765

반응식

HRID 751765 반응식
[CH:1]1([CH:7]=[CH:8][C:9]([OH:11])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:14])=O>ClCCl.CN(C=O)C>[CH:1]1([CH:7]=[CH:8][C:9]([Cl:14])=[O:11])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

5

반응물 2

HCID 24386Thionyl ChlorideHCID 2873483-Cyclohexylacrylic acid

생성물 1

HCID 566232073-Cyclohexylprop-2-enoyl chloride수율 100.1%

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6344Dichloromethane용매

실험 절차

4.22 g (27.3 mmol) of 3-cylcohexyl-2-propenoic acid are suspended in dichloromethane (30 ml), 5 drops of DMF are added and at RT 1.9 ml (164 mmol) of thionyl chloride are slowly added dropwise. The reaction mixture is heated to reflux for 2 h, cooled and concentrated to dryness on a rotary evaporator. The oily residue is taken up twice using toluene, concentrated to dryness and dried in vacuo. 4.72 g of product are obtained, which is directly reacted further.

후처리

  1. additionare slowly added dropwise
  2. temperatureThe reaction mixture is heated
  3. temperatureto reflux for 2 h
  4. temperaturecooled
  5. concentrationconcentrated to dryness on a rotary evaporator
  6. concentrationconcentrated to dryness
  7. customdried in vacuo

출처 및 근거

ORD 기록
ord-47d1e2be11584f01ba743e7402c98e7e
출처 데이터셋
uspto-grants-2008_07
특허 번호
US07405201B2

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