Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzodiazepine → N-methylbenzodiazepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzodiazepine | HCID 134664 | — |
| 반응물 | Methyl iodide sodium hydride | HCID 23686416 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | N-methylbenzodiazepine | HCID 12543525 | — |
반응 단계
The bromide 20 available from references 9 and 10 was reacted with trimethylsilyacetylene in the presence of a palladium catalyst to provide trimethylsilyl analog 52. This product was methylated with methyl iodide/sodium hydride to give the N-methyl benzodiazepine 54 (XLi 351). This was subjected to fluoride-mediated desilation to furnish 53 (XLi 350) and 55 (XLi 352).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835424B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-1b3beb3ba5df4868b8f6774c959dce1a |
| 출처 메모 | uspto-grants-2014_09 |