Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylacetonitrile → 2-Amino-5-iodobenzophenone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylacetonitrile | HCID 8794 | — |
| 반응물 | 1-Iodo-4-nitrobenzene | HCID 12495 | — |
| 반응물 | 2-Amino-5-chlorobenzophenone | HCID 12870 | — |
| 반응물 | Diethyl chlorophosphate | HCID 13139 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Benzodiazepine | HCID 134664 | — |
| 반응물 | Ethyl isocyanoacetate | HCID 533707 | — |
| 생성물 | 2-Amino-5-iodobenzophenone | HCID 12906640 | — |
반응 단계
2-Amino-5-iodo-benzophenone was prepared from p-iodonitrobenzene and phenylacetonitrile according to the literature. 2-Amino-5-chloro-benzophenone was commercially available from Acros. The benzodiazepine 60 was reacted with diethylphosphorochloridate in the presence of sodium hydride, followed by the addition of ethyl isocyanoacetate to provide the ester 62 (Hz120), as shown in Scheme 13.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835424B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-f1662cbb6fb246f4be0376cb71edfe68 |
| 출처 메모 | uspto-grants-2014_09 |