Cyclopentanecarbonyl chloride → N-[1-(3-cyclopropyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

HRID 7542

반응식

HRID 7542 반응식
[NH2:1][CH:2]([C:5]1[C:6](=[O:14])[NH:7][C:8]([CH:11]2[CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:15]1([C:20](Cl)=[O:21])[CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:11]1([C:8]2[NH:7][C:6](=[O:14])[C:5]([CH:2]([NH:1][C:20]([CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)=[O:21])[CH2:3][CH3:4])=[N:10][N:9]=2)[CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 78284Cyclopentanecarbonyl chlorideHCID 1355940716-(1-Aminopropyl)-3-cyclopropyl-1,2,4-triazin-5(4h)-one

생성물 1

HCID 135752607N-[1-(3-cyclopropyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

실험 절차

In analogy to the procedure for Example 36A, 250 mg (1.29 mmol) 6-(1-aminopropyl)-3-cyclopropyl-1,2,4-triazin-5(4H)-one, 170 mg (1.29 mmol) cyclopentanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

후처리

  1. customThe crude product is used in the next step without further purification

출처 및 근거

ORD 기록
ord-6913902c0d744d708d3052c48a047039
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087605B2

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