Cyclopentanecarbonyl chloride → N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

HRID 7545

반응식

HRID 7545 반응식
[NH2:1][CH:2]([C:5]1[C:6](=[O:15])[NH:7][C:8]([C:11]([CH3:14])([CH3:13])[CH3:12])=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:16]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]1>>[C:11]([C:8]1[NH:7][C:6](=[O:15])[C:5]([CH:2]([NH:1][C:21]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:22])[CH2:3][CH3:4])=[N:10][N:9]=1)([CH3:14])([CH3:13])[CH3:12]

참가 물질

3

반응물 2

HCID 78284Cyclopentanecarbonyl chlorideHCID 1355940906-(1-Aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4h)-one

생성물 1

HCID 135752563N-[1-(3-tert-butyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]cyclopentanecarboxamide

실험 절차

In analogy to the procedure for Example 36A, 110 mg (0.50 mmol) 6-(1-aminopropyl)-3-tert-butyl-1,2,4-triazin-5(4H)-one, 70 mg (0.50 mmol) cyclopentanecarbonyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

후처리

  1. customThe crude product is used in the next step without further purification

출처 및 근거

ORD 기록
ord-b46f015255f1488ebf4026b731b6fb22
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087605B2

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