Thionyl Chloride → HCID 66888232, 화합물
반응식
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH:4]=[CH:3][CH:2]=1.O=S(Cl)[Cl:26]>CO>[ClH:26].[N:11]1([C:9]2[CH:8]=[CH:7][CH:6]=[C:5]3[C:10]=2[N:1]=[CH:2][CH:3]=[CH:4]3)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1참가 물질
4
실험 절차
t-butyl 4-(quinolin-8-yl)piperazine-1-carboxylate (compound 32, 2.4 g, 7.66 mmol) was dissolved in methanol (50 ml) and SOCl2 was added to the solution dropwise at 0° C. The resulting solution was refluxed for 1 day and evaporated under reduced pressure. EtOAc (50 ml) was added to the residue and stirred for 2 hours to produce light yellow solid. The title compound was collected by filteration (1.7 g, 89%) as light yellow solid.
후처리
- temperatureThe resulting solution was refluxed for 1 day
- customevaporated under reduced pressure
- additionEtOAc (50 ml) was added to the residue
- customto produce light yellow solid
- customThe title compound was collected by filteration (1.7 g, 89%) as light yellow solid
출처 및 근거
- ORD 기록
- ord-3dfa716cac1a43e59248124751b2a8eb
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08835436B2
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