Cyclopentylamine → (E)-Ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate

HRID 75495

반응식

HRID 75495 반응식
[C:1]([NH:4]/[C:5](=[C:11](/[N:13]([CH3:15])C)\[CH3:12])/[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2].[CH:16]1(N)[CH2:20]C[CH2:18][CH2:17]1>CC(O)=O.O>[C:1]([NH:4]/[C:5](=[C:11](/[NH:13][CH:15]1[CH2:18][CH2:17][CH2:16][CH2:20]1)\[CH3:12])/[C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:3])[CH3:2]

참가 물질

5

반응물 2

HCID 2906CyclopentylamineHCID 54579441(E)-ethyl 2-acetamido-3-(dimethylamino)but-2-enoate2회

생성물 1

HCID 54579442(E)-Ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

(E)-ethyl 2-acetamido-3-(dimethylamino)but-2-enoate (compound 16, 1 g, 4.67 mmol) and cyclopentylamine (0.5 mL) were stirred at room temperature in AcOH (10 mL) for overnight. The reaction mixture was diluted slowly with water (10 mL) and evaporated under reduced pressure to obtain the desired product as a dark brown oil, which could be used without any further purification for the next step.

후처리

  1. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-f21a1bee4a0f4c51879b70c98fcafeea
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835436B2

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