참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hexamethyldisilazane | HCID 13838 | — |
| 반응물 | Ammonium Sulfate | HCID 6097028 | — |
| 반응물 | (E)-Ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate | HCID 54579442 | — |
| 생성물 | Ethyl 1-cyclopentyl-2,5-dimethyl-1H-imidazole-4-carboxylate | HCID 54579443 | 71.7% |
반응 단계
Ammonium sulfate (100 mg) was added to a solution of (E)-ethyl 2-acetamido-3-(cyclopentylamino)but-2-enoate (compound 18, 1.5 g, 5.9 mmol) and hexamethyldisilazane (15 mL) and refluxed overnight at 150° C. The reaction mixture was evaporated and extracted with EA and water. The organic layer was evaporated and the residue was purified with 20% methanol in CH2Cl2 to produce as a light brown solid (1.0 g, 71.4% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835436B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-d60c4c69e8b14d838b11d92221ff0a9b |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
