Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 4-Nitro-1-p-tolyl-1H-pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-nitro-1H-pyrazole | HCID 16376 | — |
| 반응물 | Tolylboronic acid | HCID 79799 | — |
| 촉매 | Cupric acetate | HCID 8895 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Nitro-1-p-tolyl-1H-pyrazole | HCID 11413030 | 31% |
반응 단계
To 4-tolylboronic acid (544 mg, 4.00 mmol), 4-nitropyrazole (226 mg, 2.00 mmol), copper (II) acetate (545 mg, 3.00 mmol), and 4 Å sieves (1.5 g) in DCM (15 mL), was added pyridine (0.32 mL, 4 mmol) at RT, and stirred for 5 h. The mixture was filtered through Celite, washing with DCM, then evaporated to dryness. The residue was purified by FCC, eluting with 0-30% ethyl acetate in cyclohexane, to give the title compound as a white solid (126 mg, 31%). LCMS (Method 3): Rt 3.93 min, m/z 204.1 [MH−].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835431B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b77fbc78aea049efbe40ef84e64179be |
| 출처 메모 | uspto-grants-2014_09 |