Valeryl chloride → N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]pentanamide

HRID 7559

반응식

HRID 7559 반응식
[NH2:1][CH:2]([C:5]1[C:6](=[O:16])[NH:7][C:8]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[C:17](Cl)(=[O:22])[CH2:18][CH2:19][CH2:20][CH3:21]>>[CH:11]1([C:8]2[NH:7][C:6](=[O:16])[C:5]([CH:2]([NH:1][C:17](=[O:22])[CH2:18][CH2:19][CH2:20][CH3:21])[CH2:3][CH3:4])=[N:10][N:9]=2)[CH2:15][CH2:14][CH2:13][CH2:12]1

참가 물질

3

반응물 2

HCID 61186Valeryl chlorideHCID 1355940676-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one

생성물 1

HCID 135752627N-[1-(3-Cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]pentanamide

실험 절차

In analogy to the procedure for Example 36A, 150 mg (0.67 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 90 mg (0.74 mmol) pentanoyl chloride and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

후처리

  1. customThe crude product is used in the next step without further purification

출처 및 근거

ORD 기록
ord-526d21388cd841819a22eea236d08838
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087605B2

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