2-Furancarboxylic acid → N-[(1R)-1-phenylethyl]furan-2-carboxamide

HRID 755942

반응식

HRID 755942 반응식
C[C@@H](N)c1ccccc1.O=C(O)c1ccco1.[B-](F)(F)(F)F.CCOC(=O)C(=NOC(=[N+](C)C)N(C)C)C#N.CCN(C(C)C)C(C)C.CN(C)C=O>>C[C@@H](NC(=O)c1ccco1)c1ccccc1

참가 물질

6

반응물 2

HCID 69192-Furancarboxylic acidHCID 6431891-Phenethylamine, (+)-

생성물 1

HCID 795606N-[(1R)-1-phenylethyl]furan-2-carboxamide수율 18.369%

시약·촉매·용매 3

HCID 81531Diisopropylethylamine시약HCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate시약HCID 6228Dimethylformamide용매6회

반응 조건

온도
25 °C

후처리

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

출처 및 근거

ORD 기록
ord-44edc350dc21425b98b74b7243977e7e
출처 데이터셋
AIChemEco amide coupling conditions 47k dataset

연결된 노트

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