Diisopropylethylamine (HCID 81531)

이름 및 식별자

우선 이름: Diisopropylethylamine
IUPAC: N-ethyl-N-propan-2-ylpropan-2-amine
현지명: N,N-다이아이소프로필에틸아민
영어명: N,N-Diisopropylethylamine
분자식: C8H19N
분자량: 129.24

이름 및 동의어

N,N-Diisopropylethylamine7087-68-5EthyldiisopropylamineDiisopropylethylamineN-EthyldiisopropylaminedieaDIPEAHunig's Base2-Propanamine, N-ethyl-N-(1-methylethyl)-1,1'-Dimethyltriethylamine5SIQ15721LNSC-147491

이름 더 보기

N,N-다이아이소프로필에틸아민N,N-디이소프로필에틸아민N-에틸-N-(1-메틸에틸)-2-프로판아민N,N-다이아이소프로필에틸아민(N,N-DIISOPROPYLETHYLAMINE)DIEPAi-Pr2NEt

DTXSID8064561RefChem:161220DTXCID3046829230-392-0N-ethyl-N-isopropylpropan-2-amineethylbis(propan-2-yl)amineN-Ethyl-N,N-diisopropylamineN-ethyl-N-propan-2-ylpropan-2-amine

데이터베이스 식별자

CAS: 7087-68-5
PubChem CID: 81531
DTXSID: DTXSID8064561
ChEBI: CHEBI:193590
UNII: 5SIQ15721L
EC Number: 230-392-0
Nikkaji: J108.742H

물성

구조 계산 물성

XLogP: 2.2
극성 표면적: 3.2 Å²
수소 결합 공여자 수: 0
수소 결합 수용자 수: 1
회전 가능 결합 수: 3
무거운 원자 수: 9
형식 전하: 0
복잡도: 59

실험 및 물리화학적 성질

Density0.742 @25 °C

Boiling Point126.5 °C @760 [mm Hg]

Vapor Pressure12.0 [mmHg]

Physical DescriptionClear colorless liquid; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점: -50 °C · <-50 °C (lit.)
끓는 점: 127 °C · 127 °C (lit.)
밀도: 0.742 g/mL · 0.742 g/mL at 25 °C (lit.)
증기압: 31 mmHg · 31 mmHg ( 37.7 °C)
굴절률: 20 · n20/D 1.457
인화점: 6 °C · 6 °C
저장 조건: 30 °C · Store below +30°C.
용해도: 물과 섞임
물리적 상태: 액체
산도 계수 (pKa): 10.98 · 10.98±0.28(Predicted)
Specific Gravity: 0.755 · 0.755 (20/4℃)
색상: 20 · APHA: <20
수소이온지수(pH): 12.3 · 12.3 (H2O, 20℃)(as an emulsion)
폭발한계: 0.7 · 0.7-6.3%(V)
수용성: 혼용 가능
BRN: 605301 · 605301
안정성: 휘발성 물질
InChI: 1S/C8H19N/c1-6-9(7(2)3)8(4)5/h7-8H,6H2,1-5H3
InChIKey: JGFZNNIVVJXRND-UHFFFAOYSA-N
SMILES: CCN(C(C)C)C(C)C
LogP: -1.8 at · -1.8 at 22.5℃
NIST: (i-C3H7)2(C2H5)N(7087-68-5)
EPA: 2 · 2-Propanamine, N-ethyl-N-(1-methylethyl)- (7087-68-5)

화학적 성질

Diisopropylethylamine (DIPEA) is a clear, colorless to light yellow liquid, insoluble in water and easily soluble in acetone and other organic solvents.

안전 및 규제

GHS 분류

GHS Classification · 6건

This chemical does not meet GHS hazard criteria for < 0.1% (1 of 2527) of reports.

Danger

H225 (97.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]；H302 (92.3%): Harmful if swallowed [Warning Acute toxicity, oral]；H318 (96.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]；H331 (91.3%): Toxic if inhaled [Danger Acute toxicity, inhalation]；H335 (91.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 2527 reports by companies from 28 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 1 of 2527 reports by companies.；There are 27 notifications provided by 2526 of 2527 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

유해성 정보

Regulatory Information · 4건

Chemical: 2-Propanamine, N-ethyl-N-(1-methylethyl)-

2-Propanamine, N-ethyl-N-(1-methylethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propanamine, N-ethyl-N-(1-methylethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 01-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13609；Status: Active Update: 24-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/28157

2-Propanamine, N-ethyl-N-(1-methylethyl)-: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryCauses burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Toxic by ingestion; [Sigma-Aldrich MSDS]

Hazard Classes and CategoriesFlam. Liq. 2 (97.8%)；Acute Tox. 4 (92.3%)；Eye Dam. 1 (96.4%)；Acute Tox. 3 (91.3%)；STOT SE 3 (91.3%)

안전 및 보호

Protective Action Criteria (PAC) · 3건

1.8 [mg/m3]

19 [mg/m3]

120 [mg/m3]

독성 정보

Adverse EffectsDermatotoxin - Skin burns.；Toxic Pneumonitis - Inflammation of the lungs induced by inhalation of metal fumes or toxic gases and vapors.

규제 정보

Regulatory Information · 4건

Chemical: 2-Propanamine, N-ethyl-N-(1-methylethyl)-

2-Propanamine, N-ethyl-N-(1-methylethyl)- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 2-Propanamine, N-ethyl-N-(1-methylethyl)- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 01-06-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/13609；Status: Active Update: 24-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/28157

2-Propanamine, N-ethyl-N-(1-methylethyl)-: Does not have an individual approval but may be used under an appropriate group standard

안전 데이터

wgk: 2
tsca: TSCA listed
ridadr: UN 2734 8/PG 2
독성: LD50 orally in Rabbit: > 200 - 500 mg/kg
HS 번호: 29211980
risk_code: 11-22-34-52/53-20/21/22-10-41-37/38-20/22-36/37/38-61
hazard_code: C,F,T
safety_code: 26-36/37/39-45-61-16-27-60-23-9-53
포장분류: II
위험 등급: 3
기존화학 물질: KE-10950
F 고인화성물질: 9-34
위험 참고 사항: Highly Flammable/Corrosive/Harmful
자연 발화 온도: 240 °C
Hazard Classifications: Acute Tox. 3 InhalationAcute Tox. 4 OralAquatic Chronic 2Eye Dam. 1Flam. Liq. 2STOT SE 3
스토리지 클래스: 3 - Flammable liquids

화학 및 산업

용도 및 제조

Uses · 2건

Used to make and/or formulate industrial products; [BASF MSDS]

Synthetic Polymer MALDI Matrix Compounds

U.S. Production2022: 50,000 - <250,000 lb；2021: 50,000 - <250,000 lb；2020: 50,000 - <250,000 lb

Industry UsesIntermediate

General Manufacturing Information · 2건

All Other Basic Organic Chemical Manufacturing

2-Propanamine, N-ethyl-N-(1-methylethyl)-: ACTIVE

응용 분야 · 2건

용도N,N-Diisopropylethylamine is used as a base in organic reactions. Used in the preparation of (-)Gambierol a marine polycyclic ether toxin. It is also used in the synthesis of potent inhibitors of human brain memapsin, a key effector in the progression of Alzheimer’s disease.

일반 설명N-Ethyldiisopropylamine (EDIA) reacts with monoactivated Michael acceptors to afford symmetrical sulfones.

제조 방법 · 1건

N,N-Diisopropylethylamine is used as a non-nucleophilic base in organic synthesis. It is prepared by the alkylation of diisopropylamine with diethyl sulphate. DIPEA can then be purified through distillation from potassium hydroxide if necessary.

상·하류 제품 정보

하류 제품

공급사50 곳

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

杭州品高化工有限公司0571-87658025 · [email protected]

연결된 노트

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N,N-다이아이소프로필에틸아민

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