Cyclohexaneacetic acid → 2-Cyclohexyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]acetamide

HRID 7562

반응식

HRID 7562 반응식
[NH2:1][CH:2]([C:5]1[C:6](=[O:16])[NH:7][C:8]([CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[N:9][N:10]=1)[CH2:3][CH3:4].[CH:17]1([CH2:23][C:24](O)=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([CH2:23][C:24]([NH:1][CH:2]([C:5]2[C:6](=[O:16])[NH:7][C:8]([CH:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)=[N:9][N:10]=2)[CH2:3][CH3:4])=[O:25])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

3

반응물 2

HCID 21363Cyclohexaneacetic acidHCID 1355940676-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one

생성물 1

HCID 1357525262-Cyclohexyl-N-[1-(3-cyclopentyl-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)propyl]acetamide

실험 절차

In analogy to the procedure for Example 58A, 150 mg (0.67 mmol) 6-(1-aminopropyl)-3-cyclopentyl-1,2,4-triazin-5(4H)-one, 96 mg (0.67 mmol) cyclo-hexylacetic acid and proportionate amounts of the other reagents are used. The crude product is used in the next step without further purification.

후처리

  1. customThe crude product is used in the next step without further purification

출처 및 근거

ORD 기록
ord-5df41889bf2647ffb1b74693fb65d127
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087605B2

연결된 노트

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