Aluminum → Avibactam Sodium

HRID 75684노트

반응식

HRID 75684 반응식
CCO/N=C(\C(N[C@@H]1C(=O)N2C(C([O-])=O)=C(SC3SC=C(C4C=C[N+](C)=CC=4)N=3)CS[C@H]12)=O)/C1N=C(NP(O)(O)=O)SN=1.[Na+:44].[O:45]=[C:46]1[N:52]2[CH2:53][C@@H:48]([CH2:49][CH2:50][C@@H:51]2[C:54]([NH-:56])=[O:55])[N:47]1[O:57][S:58]([OH:61])(=[O:60])=[O:59].N[C@H](C(O)=O)CCCNC(=N)N.ClCCCCC=CC(=C)C.[Al]>>[CH2:49]1[C@H:48]2[N:47]([O:57][S:58]([O-:61])(=[O:60])=[O:59])[C:46](=[O:45])[N:52]([CH2:53]2)[C@H:51]([C:54]([NH2:56])=[O:55])[CH2:50]1.[Na+:44]

참가 물질

6

반응물 5

HCID 5359268AluminumHCID 9852981Pyridinium, 4-(2-(((6R,7R)-2-carboxy-7-(((2Z)-2-(ethoxyimino)-2-(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)thio)-4-thiazolyl)-1-methyl-, inner saltHCID 123522792Chlorobutyl-isopreneHCID 131731870trans-7-Oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium saltHCID 178418600HCID 178418600, 화합물

생성물 1

HCID 24944097Avibactam Sodium

실험 절차

Ceftaroline fosamil, trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt (Form I) and L-Arginine were blended in a twin shell blender (Patterson-Kelly) for times ranging from 15 to 60 minutes. The blend was subsequently weighed into vials and the vials were stoppered (with or without nitrogen), sealed and stored at different conditions to monitor stability. Packaging components used were 20 ml Type I glass vial, Gray chlorobutyl-isoprene stopper and Blue Aluminum tear-off seal.

후처리

  1. customsealed

출처 및 근거

ORD 기록
ord-8a8361b9bf57490f9f9053e36ae83a81
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835455B2

반응 노트

불러오는 중…