참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | 4-Fluoroanthranilic acid | HCID 2724967 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 7-Fluoroquinazolin-4(3H)-one | HCID 135398496 | 81.9% |
반응 단계
2-amino-4-fluorobenzoic acid (100 g, 0.64 mol) and formamide (154 mL, 3.87 mol) were mixed with a catalytic amount (1 mL) of N,N-dimethylformamide. The mixture was heated to 180° C. and further stirred for 14 hours. The mixture was cooled to room temperature, and distilled water (1000 mL) was added thereto. The mixture was stirred for 30 min and filtered to obtain the title compound (86 g, 81.3%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835458B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-25bcd9b5e8a44c889d87d8e953462ed9 |
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| 출처 메모 | uspto-grants-2014_09 |
|---|
