Formamide → 7-Fluoroquinazolin-4(3H)-one

HRID 75707

반응식

HRID 75707 반응식
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>CN(C)C=O>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4](=[O:5])[NH:14][CH:12]=[N:1]2)=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 713FormamideHCID 27249674-Fluoroanthranilic acid

생성물 1

HCID 1353984967-Fluoroquinazolin-4(3H)-one수율 81.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
180 °C

실험 절차

2-amino-4-fluorobenzoic acid (100 g, 0.64 mol) and formamide (154 mL, 3.87 mol) were mixed with a catalytic amount (1 mL) of N,N-dimethylformamide. The mixture was heated to 180° C. and further stirred for 14 hours. The mixture was cooled to room temperature, and distilled water (1000 mL) was added thereto. The mixture was stirred for 30 min and filtered to obtain the title compound (86 g, 81.3%).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. distillationdistilled water (1000 mL)
  3. additionwas added
  4. stirringThe mixture was stirred for 30 min
  5. filtrationfiltered

출처 및 근거

ORD 기록
ord-25bcd9b5e8a44c889d87d8e953462ed9
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835458B2

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