Potassium Bromide → 3-[4-(3-Phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid

HRID 75775

반응식

HRID 75775 반응식
C([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:19])=[CH:13][CH:12]=2)[CH:7]=1)=[O:5])C.[K+].[Br-]>>[C:21]1([NH:20][C:18](=[O:19])[NH:17][C:14]2[CH:13]=[CH:12][C:11]([C:8]3[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[O:10][N:9]=3)=[CH:16][CH:15]=2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

3

반응물 2

HCID 253877Potassium BromideHCID 673522403-[4-(3-Phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester

생성물 1

HCID 673550113-[4-(3-Phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid수율 95.6%

실험 절차

The title compound was prepared from 3-[4-(3-phenyl-ureido)-phenyl]-isoxazole-5-carboxylic acid ethyl ester as set forth in example 8 and was obtained in 95.6% yield. Mass (ES+): 324 (M++1); IR (KBr): 3312, 1711, 1645, 1599, 1461; 1H NMR (DMSO-d6) δ: 6.97 (t, 1H), 7.28 (t, 2H), 7.45 (d, 2H), 7.59 (d, 2H), 7.71 (s, 1H), 7.87 (d, 2H), 8.76 (s, 1H), 8.96 (s, 1H).

후처리

  1. customwas obtained in 95.6% yield

출처 및 근거

ORD 기록
ord-9d69b0bec77c427ebf429443c5479d12
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835428B2

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