Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 3-(4-aminophenyl)isoxazole-5-carboxylate → 3-(4-Amino-3-Fluoro-phenyl)-isoxazole-5-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 3-(4-aminophenyl)isoxazole-5-carboxylate | HCID 53407704 | — |
| 반응물 | 3-(3-Fluoro-4-nitro-phenyl)-isoxazole-5-carboxylic acid ethyl ester | HCID 67352533 | — |
| 생성물 | 3-(4-Amino-3-Fluoro-phenyl)-isoxazole-5-carboxylic acid ethyl ester | HCID 67352661 | 55% |
반응 단계
The title compound was prepared from 3-(3-fluoro-4-nitro-phenyl)-isoxazole-5-carboxylic acid ethyl ester by following the procedure as described for the preparation of 3-(4-Amino-phenyl)-isoxazol-5-carboxylic acid ethyl ester (Example 1, Step 2) in 55% yield; MS (m/z): 250; 1H NMR (DMSO-d6) δ: 1.31 (t, 3H, CH2CH3), 4.36 (q, 2H, CH2CH3), 5.7 (s, 2H, NH2), 6.81 (t, 1H), 7.48 (d, 1H, J=9.0), 7.56 (d, 1H), 7.74 (s, 1H, 4-H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08835428B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-70dd4ddd7cfa4db1a60d4bf918efe399 |
| 출처 메모 | uspto-grants-2014_09 |