Ethyl 3-(4-aminophenyl)isoxazole-5-carboxylate → 3-(4-Amino-3-Fluoro-phenyl)-isoxazole-5-carboxylic acid ethyl ester

HRID 75795

반응식

HRID 75795 반응식
[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[C:13]([F:20])[CH:12]=2)[CH:7]=1)=[O:5])[CH3:2].C(OC(C1ON=C(C2C=CC(N)=CC=2)C=1)=O)C>>[CH2:1]([O:3][C:4]([C:6]1[O:10][N:9]=[C:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[C:13]([F:20])[CH:12]=2)[CH:7]=1)=[O:5])[CH3:2]

참가 물질

3

반응물 2

HCID 53407704Ethyl 3-(4-aminophenyl)isoxazole-5-carboxylateHCID 673525333-(3-Fluoro-4-nitro-phenyl)-isoxazole-5-carboxylic acid ethyl ester

생성물 1

HCID 673526613-(4-Amino-3-Fluoro-phenyl)-isoxazole-5-carboxylic acid ethyl ester수율 55%

실험 절차

The title compound was prepared from 3-(3-fluoro-4-nitro-phenyl)-isoxazole-5-carboxylic acid ethyl ester by following the procedure as described for the preparation of 3-(4-Amino-phenyl)-isoxazol-5-carboxylic acid ethyl ester (Example 1, Step 2) in 55% yield; MS (m/z): 250; 1H NMR (DMSO-d6) δ: 1.31 (t, 3H, CH2CH3), 4.36 (q, 2H, CH2CH3), 5.7 (s, 2H, NH2), 6.81 (t, 1H), 7.48 (d, 1H, J=9.0), 7.56 (d, 1H), 7.74 (s, 1H, 4-H).

출처 및 근거

ORD 기록
ord-70dd4ddd7cfa4db1a60d4bf918efe399
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835428B2

연결된 노트

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