HCID 67353219, 화합물 → Methyl 2-(3-(4-(3-(2,4-difluorophenyl)ureido)-3-methylphenyl) isoxazole-5-carboxamido)-3-methylbutanoate

HRID 75810노트

반응식

HRID 75810 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:27])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:22]=[C:21]([C:23]([OH:25])=O)[O:20][N:19]=2)=[CH:14][C:13]=1[CH3:26].FC1C=CC=C(F)C=1NC(=O)NC1C=CC(C2C=C(C([NH:52][CH:53]([CH:58]([CH3:60])[CH3:59])[C:54]([O:56][CH3:57])=[O:55])=O)ON=2)=CC=1C>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:27])[NH:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:22]=[C:21]([C:23]([NH:52][CH:53]([CH:58]([CH3:60])[CH3:59])[C:54]([O:56][CH3:57])=[O:55])=[O:25])[O:20][N:19]=2)=[CH:14][C:13]=1[CH3:26]

참가 물질

3

반응물 2

HCID 67353219HCID 67353219, 화합물HCID 673556003-(4-(3-(2,4-Difluorophenyl)ureido)-3-methylphenyl)isoxazole-5-carboxylic acid

생성물 1

HCID 67352872Methyl 2-(3-(4-(3-(2,4-difluorophenyl)ureido)-3-methylphenyl) isoxazole-5-carboxamido)-3-methylbutanoate

실험 절차

The title compound was prepared from 3-(4-(3-(2,4-difluorophenyl)ureido)-3-methylphenyl)isoxazole-5-carboxylic acid using the same procedure as described for preparation of the compound of step 8 of Example 98. The title compound was obtained in crude form.

출처 및 근거

ORD 기록
ord-d1889ed71c8d41579a9a0a4a0a109f47
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835428B2

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