참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 3-cyclopropyl-1H-pyrazol-5-amine | HCID 2758014 | — |
| 반응물 | 2,6-Dichloro-5-fluoro-4-iodonicotinonitrile | HCID 86620623 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-chloro-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-4-iodonicotinonitrile | HCID 86620615 | 29.5% |
반응 단계
The crude 2,6-dichloro-5-fluoro-4-iodonicotinonitrile (8.0 g, 25.2 mmol), Et3N (3.3 g, 32.8 mmol) and 5-cyclopropyl-1H-pyrazol-3-amine (3.1 g, 25.2 mmol) were placed in ACN (50 ml) and the resulting solution was heated to 80° C. for 24 hours. The reaction was cooled to room temperature, filtered, and the resulting solid was washed with cold ACN, dried, and collected to give the title compound (3.0 g, 29%). MS: Calcd.: 403. Found: [M+H]+ 404.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835465B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-7fe79be0e3314cd9b2c9e39532c9b485 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
