Chloroacetonitrile → 2-(4-Benzylpiperazin-1-yl)acetonitrile
반응식
Cl[CH2:2][C:3]#[N:4].[CH2:5]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1.CCN(CC)CC>[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([CH2:2][C:3]#[N:4])[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1참가 물질
5
실험 절차
An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.
후처리
- custombefore quenched with saturated aqueous NaHCO3 (100 ml)
- extractionThe aqueous phase was extracted with EtOAc (3×100 ml)
- dry with materialThe combined organic layer was dried over MgSO4
- concentrationconcentrated to a residue, which
- customwas used in the further reactions without any purification
출처 및 근거
- ORD 기록
- ord-f3be17d383a14b1f9a00d9ceecf8569f
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07087610B2
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