Chloroacetonitrile → 2-(4-Benzylpiperazin-1-yl)acetonitrile

HRID 7598

반응식

HRID 7598 반응식
Cl[CH2:2][C:3]#[N:4].[CH2:5]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1COCC1.CCN(CC)CC>[CH2:5]([N:12]1[CH2:17][CH2:16][N:15]([CH2:2][C:3]#[N:4])[CH2:14][CH2:13]1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

5

반응물 2

HCID 7856ChloroacetonitrileHCID 759941-Benzylpiperazine

생성물 1

HCID 38557212-(4-Benzylpiperazin-1-yl)acetonitrile

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8471Triethylamine용매

실험 절차

An excess of chloroacetonitrile (7 ml) was added in to a solution of benzylpiperazine (2 g, 10.5 mmol) in THF (100 ml) and Et3N (10 ml). The reaction was stirred for 10 hours before quenched with saturated aqueous NaHCO3 (100 ml). The aqueous phase was extracted with EtOAc (3×100 ml). The combined organic layer was dried over MgSO4 and concentrated to a residue, which was used in the further reactions without any purification.

후처리

  1. custombefore quenched with saturated aqueous NaHCO3 (100 ml)
  2. extractionThe aqueous phase was extracted with EtOAc (3×100 ml)
  3. dry with materialThe combined organic layer was dried over MgSO4
  4. concentrationconcentrated to a residue, which
  5. customwas used in the further reactions without any purification

출처 및 근거

ORD 기록
ord-f3be17d383a14b1f9a00d9ceecf8569f
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087610B2

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