Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chlorobenzothiazole → (R)-N-(benzoyl)-3-methyl-N'-[(benzothiazol-2-yl)-2-cyanoacetyl]-piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chlorobenzothiazole | HCID 11987 | — |
| 반응물 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 반응물 | (R)-N-benzoyl-3-methyl-N'-(2-cyano-acetyl)piperazine | HCID 58630501 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | (R)-N-(benzoyl)-3-methyl-N'-[(benzothiazol-2-yl)-2-cyanoacetyl]-piperazine | HCID 58680163 | 6.5% |
반응 단계
NaHMDS (1.48 ml, 1M in THF) was added into a solution of (R)-N-benzoyl-3-methyl-N′-(2-cyano-acetyl)piperazine (190 mg) and 2-chlorobenzothiazole (100 mg) in THF (10 ml). After the reaction was stirred for 10 hours, 4 ml of solution was separated and quenched with MeOH. After solvents were removed under vaccum, the residue was purified using Shimadzu automated preparative HPLC System to give (R)-N-(benzoyl)-3-methyl-N′-[(benzothiazol-2-yl)-2-cyanoacetyl]-piperazine (15.4 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087610B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-a40547b8595849ebabaf584db239ee95 |
| 출처 메모 | uspto-grants-2006_08 |