Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 76009생성일: 2026년 10월 23일
Tetrahydrofuran → N-[4-chloro-2-(triazolo[4,5-b]pyridin-1-yl)phenyl]-4-[(E)-N-hydroxy-C-methylcarbonimidoyl]benzenesulfonamide
https://huagongshe.com/ko/reaction/76009
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Hydroxyamine hydrochloride | HCID 443297 | — |
| 반응물 | 4-acetyl-N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)benzenesulfonamide | HCID 57378404 | — |
| 촉매 | Titanium tetraethoxide | HCID 76524 | — |
| 용매 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 생성물 | N-[4-chloro-2-(triazolo[4,5-b]pyridin-1-yl)phenyl]-4-[(E)-N-hydroxy-C-methylcarbonimidoyl]benzenesulfonamide | HCID 59428153 | — |
반응 단계
A 4 mL vial was charged with 4-acetyl-N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-benzenesulfonamide (synthesized according to general procedures F and G, 100 mg, 0.23 mmol), hydroxylamine hydrochloride (49 mg, 0.70 mmol), and 2 mL THF. The resultant slurry was mixed well, then titanium ethoxide (98 μL, 47 mmol) was added and the mixture heated to 60° C. overnight. The reaction mixture was subsequently diluted with ˜2 mL of acetonitrile/H2O and purified by reversed phase HPLC to afford N-(4-chloro-2-[1,2,3]triazolo[4,5-b]pyridin-1-yl-phenyl)-4-{1-[(E)-hydroxyimino]-ethyl}benzenesulfonamide: MS (ES) M+H expected 443.0, found 443.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08835468B2 |
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| 출처 데이터셋 | uspto-grants-2014_09 |
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| ORD ID | ord-21578a6e5afc47588c98aebf27174ab7 |
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| 출처 메모 | uspto-grants-2014_09 |
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