Propionyl chloride → Bis-benzyloxy benzoic acid

HRID 76090노트

반응식

HRID 76090 반응식
C[O:2][C:3](=[O:26])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:5]=1[O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(Cl)(=O)CC>>[CH2:11]([O:10][C:6]1[C:5]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:4]([CH:9]=[CH:8][CH:7]=1)[C:3]([OH:26])=[O:2])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

3

반응물 2

HCID 62324Propionyl chlorideHCID 10665397Methyl 2,3-bis(benzyloxy)benzoate

생성물 1

HCID 10520703Bis-benzyloxy benzoic acid

실험 절차

In another embodiment the compounds can be prepared as shown in Scheme III. A nitroaniline (1) can be reacted with propionyl chloride to yield nitro-phenyl-propionamide (2). NaH can then be added to a solution of (2) in anhydrous THF followed by iodomethane to give pure product nitro-phenyl-N-methyl-propionamide (3).

후처리

  1. customIn another embodiment the compounds can be prepared

출처 및 근거

ORD 기록
ord-08fba97b67914e08bba8c8f330580161
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835464B2

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