Potassium Carbonate → 2-Ethynyl-5-isopropoxypyridine

HRID 76124노트

반응식

HRID 76124 반응식
[CH:1]([O:4][C:5]1[CH:6]=[CH:7][C:8]([CH:11]=O)=[N:9][CH:10]=1)([CH3:3])[CH3:2].[C:13]([O-])([O-])=O.[K+].[K+].[N+](=C(P(=O)(OC)OC)C(=O)C)=[N-]>CO.CCOC(C)=O>[C:11]([C:8]1[CH:7]=[CH:6][C:5]([O:4][CH:1]([CH3:3])[CH3:2])=[CH:10][N:9]=1)#[CH:13]

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 797940465-IsopropoxypicolinaldehydeHCID 136023029(1E)-1-diazo-1-dimethoxyphosphorylpropan-2-one

생성물 1

HCID 747887042-Ethynyl-5-isopropoxypyridine

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To 1.00 g (6.05 mmol) 5-isopropoxypicolinaldehyde in 20 mL methanol are added 1.67 g (12.1 mmol) K2CO3 followed by 1.4 g (7.26 mmol) dimethyl 1-diazo-2-oxopropylphosphonate. After stirring at r.t. over the weekend the reaction mixture is diluted with EtOAc and washed consecutively with NaHCO3 solution and water. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo.

후처리

  1. washwashed consecutively with NaHCO3 solution and water
  2. dry with materialThe organic layer is dried with Na2SO4
  3. customthe solvent is removed in vacuo

출처 및 근거

ORD 기록
ord-a170e6da9b254ca38b9dff72e944b64c
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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