Ethyl Bromide → 2-Bromo-5-ethoxypyridine

HRID 76129

반응식

HRID 76129 반응식
Br[CH2:2][CH3:3].C([O-])([O-])=O.[K+].[K+].[Br:10][C:11]1[CH:16]=[CH:15][C:14]([OH:17])=[CH:13][N:12]=1>C(#N)C>[Br:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:2][CH3:3])=[CH:13][N:12]=1

참가 물질

5

반응물 3

HCID 6332Ethyl BromideHCID 11430Potassium CarbonateHCID 27628652-Bromo-5-hydroxypyridine

생성물 1

HCID 234368922-Bromo-5-ethoxypyridine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

2.51 g (22.99 mmol) 1-bromoethane and 1.99 g (14.37 mmol) K2CO3 are added to a mixture of 1.0 g (5.75 mmol) 2-bromo-5-hydroxypyridine in 100 mL ACN. The mixture is stirred at reflux over night. Then the reaction mixture is poured onto water and extracted with TBME. The organic layer is dried with Na2SO4 and the solvent is removed under vacuo. The residue is purified by column chromatography (silica gel, PE/EtOAC 1/1).

후처리

  1. temperatureat reflux over night
  2. additionThen the reaction mixture is poured onto water
  3. extractionextracted with TBME
  4. dry with materialThe organic layer is dried with Na2SO4
  5. customthe solvent is removed under vacuo
  6. customThe residue is purified by column chromatography (silica gel, PE/EtOAC 1/1)

출처 및 근거

ORD 기록
ord-36769e8c1de347da8d1796f0a24d3516
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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