Sodium Iodide → [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Iodide	HCID 5238	—
반응물	Diisopropylethylamine	HCID 81531	—
반응물	1H-Pyrazol-3-amine, 5-methyl-	HCID 93146	—
반응물	4,6-Dichloro-2[[(4-methoxyphenyl)methyl]thio]pyrimidine	HCID 13413724	—
용매	1-Butanol	HCID 263	—
생성물	[6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine	HCID 178419077	—

반응 조건

온도	120 °C

반응 단계

To a solution of above-prepared 4,6-dichloro-2-(4-methoxy-benzylsulfanyl)-pyrimidine (915 mg, 3.04 mmol) and 3-amino-5-methylpyrazole (310 mg, 3.19 mmol) in BuOH (20 mL) is added diisopropylethylamine (0.56 mL, 3.19 mmol) followed by sodium iodide (455 mg, 3.04 mmol). The reaction mixture is stirred for 15 hours at 120° C. The solvent is removed in vacuo and the residue is purified by flash chromatography (SiO2, hexane/AcOEt gardient) to give [6-chloro-2-(4-methoxy-benzylsulfanyl)-pyrimidin-4-yl)-(5-methyl-2H-pyrazol-3-yl)-amine.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07087603B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-1178eba2922a40e785961547df669987
출처 메모	uspto-grants-2006_08