Monobenzone → 5-(p-Hydroxyphenoxy)pyrimidine
반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:2]1C=CC=CC=1.BrC1[CH:18]=[N:19][CH:20]=[N:21]C=1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C.O>[OH:15][C:12]1[CH:11]=[CH:10][C:9]([O:8][C:1]2[CH:2]=[N:21][CH:20]=[N:19][CH:18]=2)=[CH:14][CH:13]=1참가 물질
6
반응 조건
- 온도
- 120 °C
실험 절차
To 1.00 g (4.99 mmol) 4-(benzyloxy)phenol and 794 mg (4.99 mmol) 5-bromo-pyrimidine in 5 mL DMF are added 3.25 g (9.99 mmol) Cs2CO3 and the reaction mixture is stirred at 120° C. for 6 h in a microwave oven. Then the reaction mixture is diluted with water and extracted with EtOAc. The organic layer is dried with Na2SO4 and the solvent is removed in vacuo. The residue is purified by HPLC (MeOH/H2O/NH3).
후처리
- extractionextracted with EtOAc
- dry with materialThe organic layer is dried with Na2SO4
- customthe solvent is removed in vacuo
- customThe residue is purified by HPLC (MeOH/H2O/NH3)
출처 및 근거
- ORD 기록
- ord-e7978093a2dc4120954dbcd795fa8f7e
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08835472B2
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