Aluminium lithium hydride → 2-(6-Chloropyridin-3-yl)ethan-1-amine

HRID 76147노트

반응식

HRID 76147 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][C:9]([NH2:11])=O)=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][NH2:11])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 532788782-(6-Chloropyridin-3-YL)acetamide

생성물 1

HCID 204834902-(6-Chloropyridin-3-yl)ethan-1-amine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 2.00 g (11.7 mmol) 2-(6-chloropyridin-3-yl)-acetamide in 50 mL THF at 0° C. are added 12.9 ml LAH (c=1 mol/l in THF) by a dropping funnel. Cooling is removed and the reaction mixture is stirred for 1 h at r.t., then 8 ml LAH (c=1 mol/l in THF) are added and the reaction mixture is stirred at r.t. over night. The reaction is carefully quenched by the addition of 2 ml of an aq. NaHCO3 solution (10%). The mixture is filtrated and the solvent is removed under reduced pressure. The crude product is used without further purification.

후처리

  1. temperatureCooling
  2. customis removed
  3. addition8 ml LAH (c=1 mol/l in THF) are added
  4. stirringthe reaction mixture is stirred at r.t. over night
  5. customThe reaction is carefully quenched by the addition of 2 ml of an aq. NaHCO3 solution (10%)
  6. filtrationThe mixture is filtrated
  7. customthe solvent is removed under reduced pressure
  8. customThe crude product is used without further purification

출처 및 근거

ORD 기록
ord-6fa8e2e68557410f80bfcc1187747a94
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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