Sulfuric Acid → N-(2-(4-Bromophenyl)propan-2-YL)acetamide

HRID 76161노트

반응식

HRID 76161 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](O)([CH3:10])[CH3:9])=[CH:4][CH:3]=1.[OH:12]S(O)(=O)=O.[C:17](#[N:19])[CH3:18]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([NH:19][C:17](=[O:12])[CH3:18])([CH3:10])[CH3:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 6342AcetonitrileHCID 126819202-(4-Bromophenyl)propan-2-ol

생성물 1

HCID 39616691N-(2-(4-Bromophenyl)propan-2-YL)acetamide

실험 절차

To 21.0 g (97.6 mmol) 2-(4-bromophenyl)-propan-2-ol in 1 L ACN are added 16.1 mL conc. H2SO4 dropwise while keeping the temperature at 20° C. The resulting mixture is stirred at r.t. over night. The solvent is removed in vacuo and the residue is partitioned between water and diethylether. The organic layer is washed with water (2×), sat. aq. NaHCO3 solution (2×) and water again (1×). The solution is dried with MgSO4 and the solvent is removed in vacuo. The crude product is triturated with PE.

후처리

  1. customat 20° C
  2. customThe solvent is removed in vacuo
  3. customthe residue is partitioned between water and diethylether
  4. washThe organic layer is washed with water (2×), sat. aq. NaHCO3 solution (2×) and water again (1×)
  5. dry with materialThe solution is dried with MgSO4
  6. customthe solvent is removed in vacuo
  7. customThe crude product is triturated with PE

출처 및 근거

ORD 기록
ord-a749d125b04e4af1b21bf3151fe5dd09
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08835472B2

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