참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate | HCID 66611490 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-(4-((4-Ethoxyphenyl)ethynyl)phenyl)propan-2-amine hydrochloride | HCID 66610681 | — |
반응 단계
To 3.30 g (8.70 mmol) tert-butyl 1-(4-((4-ethoxyphenyl)ethynyl)phenyl)propan-2-yl-carbamate (I60) in 40 mL MeOH are added 20 mL (25 mmol) HCl (1.25M in MeOH). The mixture is stirred at 70° C. for 7 h. The solvent is removed in vacuo and the crude product is triturated with DIPE and dried in normal atmosphere.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835472B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-9977905a0b844ee4aae5f5837004ce90 |
|---|
| 출처 메모 | uspto-grants-2014_09 |
|---|
